Can it lead to early detection of colorectal cancer? Discovery of genetic markers in the gut

Can Gut Bacteria Genes Predict Cancer?

In recent years, the relationship between the intestinal environment and health has been the focus of much attention. Numerous types of bacteria coexist in the intestines, and it is believed that the substances produced by these bacteria and the interaction between the intestinal bacteria and our bodies affect the development of various diseases.

The research conducted by Fujita Medical College has now shown the possibility of early detection of colorectal cancer using genetic information of intestinal bacteria.

Key points of the research

Focus on 5-alpha-reductase gene (5ar): The research team focused on the 5ar gene possessed by intestinal bacteria. This gene is involved in the metabolism of certain substances and is thought to be closely related to the development of colorectal cancer.

5ar gene decreases with the progression of colorectal cancer: The study revealed that the amount of 5ar gene in intestinal bacteria decreases with the progression of colorectal cancer.

Expectations for early detection: Using the 5ar gene as an indicator, it may be possible to predict the risk of developing cancer from the early stage of colorectal cancer, the adenoma stage.

What is the intestinal gene marker test?

What was developed in this research is a new testing method called the "intestinal gene marker test. In this test, DNA of intestinal bacteria is extracted from samples such as stool, and the risk of colorectal cancer is assessed by examining the amount of 5ar genes.

Advantages of this test

Early detection: May evaluate the risk of colorectal cancer in its early stages.

Simplicity: The test is easy to perform, requiring only a stool or other sample to be collected.

Prevention: If a high risk is detected, preventive measures can be taken, such as lifestyle modification and the intake of prebiotics (dietary fiber that feeds beneficial bacteria).

Future Prospects

This test is still in the research stage, and further studies are needed before it can be put into practical use. However, the results of this research are expected to be a major step toward early detection and prevention of colorectal cancer.

Colorectal Cancer and Intestinal Environment

Westernization of lifestyle and high-fat, low-fiber diets are among the factors that increase the risk of developing colorectal cancer. The intestinal environment is susceptible to these factors, and it has been pointed out that an imbalance in intestinal bacteria may increase the risk of colorectal cancer.

Conclusion

This study was an important step forward in elucidating the relationship between the intestinal environment and colorectal cancer. Let us hope that the results of this research will lead to a future in which more people are free from colorectal cancer.